Odessa to Big Bend: Epic West Texas Road Trip & Top Stops

Covering roughly 300 miles, the drive from Odessa to Big Bend National Park takes about 5½–6 hours of wheel time. You’ll move from wide-open prairies through historic ranch towns into the dramatic desert landscapes that define West Texas.
Primary Route: I-10 West → TX-18 South → US-385
- I-10 West to Monahans: 33 mi to Exit 83.
- TX-18 South to Fort Stockton: 50 mi—last major services until Marathon.
- US-385 South through Marathon: 55 mi to the US-90 junction; turn east briefly, then continue south on US-385 into Big Bend’s eastern entrance at Persimmon Gap.
- To Panther Junction: Another 40 mi inside the park.
Alternate Scenic Route: FM 1776 → US 67 → Alpine → TX 118
- From Monahans, head 5 mi south on TX-18, then turn right onto FM 1776.
- Follow FM 1776 through Coyanosa until it merges with US-67—about 50 mi to US-90.
- Veer right on US-90 into Alpine. After Sul Ross State University, take a left on TX-118.
- Ride 78 mi on TX-118 to Terlingua/Study Butte Junction. Turn right on TX-170 for Lajitas and Big Bend Ranch State Park, or continue straight 3 mi to the national park entrance.
Estimated Distances & Drive Times
- Odessa → Monahans (I-10): 33 mi, 30 min
- Monahans → Fort Stockton (TX-18): 50 mi, 50 min
- Fort Stockton → Marathon (US-385): 55 mi, 1 hr
- Marathon → Persimmon Gap: 30 mi, 40 min
- Alternate via Alpine: ~280 mi total, 5–5½ hrs
Must-See Stops Along the Way
- Monahans Sandhills State Park: Climb the dunes for sunrise photo ops.
- Fort Stockton: Tour the historic fort and Annie Riggs Museum.
- Marathon: Grab coffee at the Gage Hotel or browse local artisan shops.
- Alpine: Stroll the arts district, refuel, and sample West Texas barbecue.
Road Trip Tips & Safety
- Fuel & Supplies: Top off gas in Monahans, Fort Stockton, or Marathon—stations can be 100+ mi apart.
- Hydration: Bring at least one gallon of water per person; desert heat is relentless.
- Vehicle Check: Inspect tires, brakes, fluid levels, and carry a basic repair kit.
- Wildlife & Speed Limits: Observe the 45 mph park limit and watch for deer, javelina, and distracted drivers.
- Emergency Preparedness: Cell service is spotty—carry paper maps, a flashlight, and know your roadside assistance number.
Coming from Midland?
If you’re starting in Midland, see our Drive from Midland page for the fastest routes and stops.